鎵�璎傛簴(zh菙n)鍒嗗瓙婵�鍏�锛屾槸鎸囧彈婵�浜岃仛楂旀墍鐢�(ch菐n)鐢熺殑婵�鍏�銆備箣鎵�浠ョ敘(ch菐n)鐢熺ū鐐烘簴(zh菙n)鍒嗗瓙锛屾槸鍥�?y脿n)妯楊幗鐨囨瑺鈧�(w臎n)瀹氱殑鍒嗗瓙锛屾槸鍦ㄦ縺鍏夋贩鍚堟埃楂斿彈鍒板�栦��(l谩i)鑳介噺鐨勬縺鐧�(f膩)鎵�寮曡捣鐨勪竴绯诲垪鐗╃悊鍙婂寲瀛�(xu茅)鍙嶆噳(y墨ng)涓�鏇剧��(j墨ng)褰㈡垚浣嗚綁(zhu菐n)鐬�鍗抽�濈殑鍒嗗瓙锛屽叾澹藉懡鍍呯偤骞惧崄姣�寰�绉�銆� 婧�(zh菙n)鍒嗘縺鍏夋槸涓�绋�姘ｉ珨鑴堟矕婵�鍏�锛屾墍鐢�(ch菐n)鐢熺殑鏄�娉㈤��(zh菐ng)鐐�193nm鐨勬簴(zh菙n)鍒嗗瓙婵�鍏夛紝瀹冩槸涓�绋�瓒呯传澶栫窔鍏夋��锛屾�ゆ尝闀�(zh菐ng)鐨勬縺鍏夊惛鏀惰寖鍦嶇獎锛屾縺鍏夌殑鑳介噺骞句箮瀹屽叏琚�瑙掕啘涓婄毊绱�(x矛)鑳炲拰鍩鸿唱(zh矛)鍚告敹锛岃秴閬�(gu貌)閫欏��(g猫)鑼冨湇鐨勭祫绻斾笉鏈�(hu矛)鍚告敹鍒版縺鍏�锛屾瘡涓�鍊�(g猫)婵�鍏夎剤娌栧彲浠ュ垏鍓�0.2鍒�0.25um鍘氬害鐨勭敓鐗╃祫绻旓紝鎵�浠ュ懆鍦嶇殑绲勭箶涓嶆渻(hu矛)鎼嶅偡銆�
    婧�(zh菙n)鍒嗗瓙婵�鍏夎垏鐢熺墿绲勭箶浣滅敤鏅�(sh铆)鐧�(f膩)鐢熺殑涓嶆槸鐔辨晥鎳�(y墨ng)锛岃�屾槸鍏夊寲鍙嶆噳(y墨ng)锛屾墍璎傚厜鍖栧弽鎳�(y墨ng)锛屾槸鎸囩祫绻斿彈鍒伴仩(yu菐n)绱�澶栧厜婵�鍏変綔鐢ㄦ檪(sh铆)锛屾渻(hu矛)鏂疯�傚垎瀛愪箣闁撶殑绲�(ji茅)鍚堥嵉锛屽皣绲勭箶鐩存帴鍒嗛洟鎴愭彯鐧�(f膩)鎬х殑纰庣墖鑰屾秷鏁ｇ劇(w煤)韫わ紝灏�(du矛)鍛ㄥ湇绲勭箶鍓囨矑(m茅i)鏈夊奖闊�锛岄仈(d谩)鍒板皪(du矛)瑙掕啘鐨勯噸濉戠洰鐨�锛岃兘绮剧⒑娑堣瀺浜虹溂瑙掕啘闋�(y霉)瑷�(j矛)鍘婚櫎鐨勯儴鍒嗙┖闁撶簿纰哄害閬�(d谩)绱�(x矛)鑳炴按骞筹紝涓嶆悕鍌峰懆鍦嶇祫绻�銆傚畠鐨勬尝闀�(zh菐ng)鐭�锛屼笉鏈�(hu矛)绌块�忎汉鐨勭溂瑙掕啘锛屽洜姝ゅ皪(du矛)浜庣溂鐞冨収(n猫i)閮ㄧ殑绲勭箶娌�(m茅i)鏈変换浣曚笉鑹�鐨勪綔鐢�銆�
    婧�(zh菙n)鍒嗗瓙婵�鍏夊湪閱�(y墨)瀛�(xu茅)涓婁富瑕佺敤浜庡眻鍏変笉姝ｇ殑娌荤檪锛屽�傜敤PRK銆丩ASIK銆丩ASEK绛夋柟娉曢��(j矛n)琛屽眻鍏変笉姝ｇ殑娌荤檪锛屾槸鐩�鍓嶈嚚搴婁笂鎳�(y墨ng)鐢ㄦ瘮杓冩櫘閬�銆佸畨鍏�銆佸揩鎹�銆佹湁鏁堛�佺┅(w臎n)瀹氱殑灞堝厜涓嶆�ｆ不鐧傛柟娉�銆�

    婧�(zh菙n)鍒嗗瓙婵�鍏夐�栧厛琚�鎳�(y墨ng)鐢ㄥ湪宸ユキ(y猫)涓�:
    缇庡湅(gu贸)IBM鍏�鍙搁枊濮嬩娇鐢ㄥ苟涓旀敼閫�(j矛n)婧�(zh菙n)鍒嗗瓙婵�鍏夋妧琛�(sh霉)锛屼富瑕佹噳(y墨ng)鐢ㄥ湪瑷�(j矛)绠楁��(j墨)鑺�鐗囩殑鍒堕�犱互鍙婂�戞枡鐗╄��(zh矛)涓婅潟鍒荤簿纰虹殑鍦栧舰銆�
    1980骞碔BM鍏�鍙告��(y墨ng)鐢�193nm婧�(zh菙n)鍒嗗瓙婵�鍏夊埁鍏夐墕鐭�銆�
    1982骞碔BM灏囨簴(zh菙n)鍒嗗瓙婵�鍏夋妧琛�(sh霉)鎳�(y墨ng)鐢ㄥ湪鍗婂皫(d菐o)楂斿厜鍒诲伐钘濅腑.
    1986骞碅T&T璨濈埦瀵�(sh铆)椹�(y脿n)瀹ょ爺鍒跺嚭鑷�(t谩i)婧�(zh菙n)鍒嗗瓙婵�鍏夊垎姝ユ姇褰卞厜鍒绘��(j墨).
    鐩�鍓嶆��(zh菙n)鍒嗗瓙婵�鍏夊凡寤ｆ硾鎳�(y墨ng)鐢ㄥ湪鑷ㄥ簥閱�(y墨)瀛�(xu茅)浠ュ強绉戝��(xu茅)鐮旂┒鑸囧伐妤�(y猫)鎳�(y墨ng)鐢ㄦ柟闈�锛屽�傦細閴嗗瓟銆佹��(bi膩o)瑷樿〃闈㈣檿鐞嗐�佹縺鍏夊寲瀛�(xu茅)姘ｇ浉娌夌��锛岀墿鐞嗘埃鐩告矇绌�锛岀�侀牠鑸囧厜瀛�(xu茅)閺＄墖鍜岀�呮櫠鍦撶殑娓呮綌绛夋柟闈�,寰�姗�(j墨)闆荤郴绲�(t菕ng)鐩搁棞(gu膩n)鐨勫井鍒堕�犳妧琛�(sh霉).
    婧�(zh菙n)鍒嗗瓙婵�鍏変簬90骞翠唬濮嬪湪閱�(y墨)瀛�(xu茅)涓婂緱鍒伴亱(y霉n)鐢�锛�
    鐪肩�戯細浣跨��193nm婧�(zh菙n)鍒嗗瓙婵�鍏夐��(j矛n)琛孡ASIK鎵嬭��(sh霉)锛岀煰娌诲眻鍏変笉姝�(杩戣��銆侀仩(yu菐n)瑕�銆佹暎鍏�)銆�
    1983骞�锛屽摜鍊�姣斾簽澶у��(xu茅)鐨凪D.Stephen Trokel浠ュ強IBM鐨凷rinicasan棣栧厛鎻愬嚭鐢ㄦ縺鍏夋不鐧傝繎瑕栫殑妲�(g貌u)鎬�锛屽苟鍦ㄥ嫊(d貌ng)鐗╄�掕啘涓婇枊濮嬪��(sh铆)椹�(y脿n)銆�
    1987骞达紝Trokel绛変汉灏嘔BM鍏�鍙哥��(f膩)鏄庣敤浠ュ垏鍓茶姱鐗囩殑婧�(zh菙n)鍒嗗瓙婵�鍏夌敤浜庝汉鐪艰�掕啘涓�锛屾噳(y墨ng)鐢ㄦ簴(zh菙n)纰鸿▓(j矛)閲忕殑婧�(zh菙n)鍒嗗瓙婵�鍏夌洿鎺ユ苯鍖栬�掕啘鐨勯儴鍒嗙祫绻�锛屼互閬�(d谩)鍒版敼璁婄溂瑙掕啘鏇插害鐨勭洰鐨�銆�
    涔濆崄骞翠唬鍒濓紝缇庡湅(gu贸)FDA闁嬪�嬫��(zh菙n)鍒嗗瓙婵�鍏夎�掕啘琛ㄩ潰鍒囧墛琛�(sh霉)(Photorefractive keratectomy,PRK)鐨勮嚚搴婂��(sh铆)椹�(y脿n)锛岄枊濮嬩簡婵�鍏夋不鐧傝繎瑕�銆�
    1990骞达紝Dr Pallikaris銆丅uratto锛孏alvis鍜� Dr Ruiz绲�(ji茅)鍚圓LK鐨勬妧琛�(sh霉)鑸囧厛閫�(j矛n)婵�鍏夊剙绲�(ji茅)鍚堣�岀櫦(f膩)鏄庝簡婧�(zh菙n)鍒嗗瓙婵�鍏夎�掕啘鍘熶綅纾ㄩ懖琛�(sh霉)(Laser-Assisted in Situ Keratomileusis,LASIK)銆傜稉(j墨ng)閬�(gu貌)骞惧勾鐨勮嚚搴婂��(sh铆)椹�(y脿n)鏁堟灉璺熻工锛�1995骞�10鏈團DA鏈�绲傛�ｅ紡鎵规��(zh菙n)PRK鎵嬭��(sh霉)鍙�浠ユ不鐧�600搴︿互鍏�(n猫i)鐨勮繎瑕�锛�400搴︿互鍏�(n猫i)鐨勬暎鍏�銆�
    1995鑷�1999骞达紝F(xi脿n)DA鍙堢浉绻兼壒婧�(zh菙n)浜�1200搴︿互鍏�(n猫i)鐨勮繎瑕�銆�600搴︿互鍏�(n猫i)鏁ｅ厜鍜�600搴︿互鍏�(n猫i)閬�(yu菐n)瑕栫殑LASIK娌荤檪銆�
    1993骞翠腑鍦�(gu贸)琛�(w猫i)鐢熼儴棣栨�℃壒婧�(zh菙n)寮曢��(j矛n)鐨勫叐鑷�(t谩i)婧�(zh菙n)鍒嗗瓙婵�鍏夋不鐧傚剙鍦ㄥ寳浜�鍚屼粊閱�(y墨)闄�浠ュ強鍗�(xi茅)鍜岄啱(y墨)闄㈡噳(y墨ng)鐢≒RK鎶�琛�(sh霉),1995骞撮枊濮嬫噳(y墨ng)鐢↙ASIK鎶�琛�(sh霉)銆�
    1996骞磋嚭(t谩i)鐏ｉ�氶亷(gu貌)浜洪珨瀵�(sh铆)椹�(y脿n)鑰屾�ｅ紡鏍告��(zh菙n)浣跨敤PRK鎶�琛�(sh霉).
    1997骞存剰澶у埄Rovigo閱�(y墨)闄㈢溂绉戜腑蹇僊assino lamellion MD鐧�(f膩)鏄庢簴(zh菙n)鍒嗗瓙婵�鍏夎�掕啘涓婄毊纾ㄩ懖琛�(sh霉)(laser epithelial keratomileusis,LASEK)
    1999骞�,娉㈠墠寮曞皫(d菐o)婵�鍏夋墜琛�(sh霉)鎶�琛�(sh霉)(Customized LASIK)琚�闁嬬��(f膩);
    2001骞�,缇庡湅(gu贸)闁嬪�嬪湪鑷ㄥ簥鎳�(y墨ng)鐢ㄦ�ら��(xi脿ng)鎶�琛�(sh霉)銆�
    2002骞�10鏈堬紝F(xi脿n)DA鏍告簴(zh菙n)浜嗘�ら��(xi脿ng)鎶�琛�(sh霉)锛岀��浜屽勾5鏈堥枊濮嬫�ｅ紡鏅�鍙�銆�
    鐨�鑶氾細浣跨��308nm婧�(zh菙n)鍒嗗瓙婵�鍏夋不鐧傜櫧鐧滈ⅷ(f膿ng)銆侀妧灞戠梾鍜岄亷(gu貌)鏁忔�х毊鐐�銆�
    蹇冭��绠�:婧�(zh菙n)鍒嗗瓙婵�鍏夊湪蹇冭��绠＄柧鐥呬腑涓昏�佺敤浜庢不鐧傚啝蹇冪��銆佸懆鍦嶈��绠＄柧鐥�銆佸績鑷熺摚鑶滅梾銆佸厛澶╂�у績鑷熺梾鍜岃偉鍘氭�у績鑲岀梾绛�銆�
    鐩存帴蹇冭倢琛�閬�(y霉n)閲嶅缓琛�(sh霉)(direct myocardial revascularization锛孌MR)锛屼篃绋辩偤缍�(j墨ng)蹇冭倢琛�閬�(y霉n)閲嶅缓琛�(sh霉)(transmyocardial revascularization锛孴MR)鎴栨縺鍏夊績鑲岃��閬�(y霉n)閲嶅缓琛�(sh霉)(transmyocardial laser revascularization锛孴MLR)锛屾槸杩戝勾渚�(l谩i)鎳�(y墨ng)鐢ㄤ簬蹇冭嚐澶栫�戣嚚搴婄殑鏂版妧琛�(sh霉)銆�
    缍�(j墨ng)鐨�鐩存帴蹇冭倢琛�閬�(y霉n)閲嶅缓琛�(sh霉)(percutaneous direct myocardial revascularization锛孭DMR)鏄�鍦═MR鎶�琛�(sh霉)鍩虹��(ch菙)涓婄櫦(f膩)灞曡捣渚�(l谩i)鐨勭敤浜庡績鑷熷収(n猫i)绉戣嚚搴婄殑涓�绋�鏂板瀷鍐犲績鐥呬粙鍏ユ不鐧傛妧琛�(sh霉)锛屾槸鍐犲績鐥呮不鐧傚彶涓婄殑涓�闋�(xi脿ng)鏂伴��(j矛n)灞�銆傞�欎簺閮界偤閬�(gu貌)鍘诲父瑕�(gu墨)鍏�(n猫i)澶栫�戞不鐧備笉鑳芥湁鏁堢殑娌荤檪鐨勫啝蹇冪梾鐥呬汉鎻愪緵浜嗕竴绋�鏂扮殑鏂规硶銆�

    婧�(zh菙n)鍒嗗瓙婵�鍏夋不鐧傝繎瑕栫溂鏈�鏃╂槸1985骞寸編鍦�(gu贸)閱�(y墨)鐢熼枊濮嬪湪鑷ㄥ簥鎳�(y墨ng)鐢ㄧ殑锛岃繎骞翠締(l谩i)鐧�(f膩)灞曡繀閫燂紝涔濆崄骞翠唬鍒濆偝鍏ヤ腑鍦�(gu贸)銆傛簴(zh菙n)鍒嗗瓙婵�鍏夋不鐧傞珮銆佷腑銆佷綆搴﹁繎瑕栫殑鎵嬭��(sh霉)鏁堟灉閬�(yu菐n)閬�(yu菐n)鍎�(y艒u)浜庝互寰�鐨勫眻鍏夋墜琛�(sh霉)锛屽洜姝�锛屽唬鐐哄叏涓栫晫鐨勭溂绉戦啱(y墨)甯�鎵�鐭氱洰銆備絾浠嶆湁寰堝�氫汉灏�(du矛)瀹冪敘(ch菐n)鐢熸嚪鐤�锛屾�曠溂鐫涜��鎵撶┛銆佺噿鐒�銆�
    涓�鑸�渚�(l谩i)瑾�(shu艒)锛屾簴(zh菙n)鍒嗗瓙婵�鍏夋槸娉㈤暦(zh菐ng)寰堢煭鐨勭传澶栧厜锛屽畠鑸囩敓鐗╃祫绻旂櫦(f膩)鐢熺殑鏄�鍏夊寲瀛�(xu茅)鏁堟噳(y墨ng)鑰屼笉鏄�鐔辨晥鎳�(y墨ng)锛屽洜姝�锛屼笉鏈�(hu矛)鐢�(ch菐n)鐢熺啽鎼嶅偡锛屾洿璜囦笉涓婄噿鐒�銆�
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